| REVIEW ARTICLE |
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| Year : 2022 | Volume
: 7
| Issue : 1 | Page : 1-9 |
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Nonalcoholic steatohepatitis-induced hepatocellular carcinoma
Abdulrahman Mohammed Hakami, Erwa Elmakki
Department of Internal Medicine, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia
Correspondence Address:
Dr. Abdulrahman Mohammed Hakami
Department of Medicine, College of Medicine, Jazan University, Jazan
Saudi Arabia
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/KKUJHS.KKUJHS_1_22
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The incidence and prevalence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH)-related cirrhosis is globally increasing, especially among communities with sedentary lifestyles. NASH-related liver cirrhosis is an emerging etiology of liver cancer. Given the increasing rates of obesity and the other risk factors of NAFLD/NASH such as diabetes mellitus, dyslipidemia, hypertension, and metabolic syndrome, NASH-related liver cancer will remain a challenging disease in the coming decades. Recent reports have shown that NASH also can cause hepatocellular carcinoma (HCC) directly without causing liver cirrhosis, the so-called noncirrhotic liver cancer. Furthermore, the pathogenicity of noncirrhotic HCC caused by NASH is not well understood and needs more future research. In the present time, NASH-related HCC has become one of the leading indications of liver transplantation. However, as the major risk factors of NASH are controllable, NASH-related HCC is a potentially preventable condition.
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